paediatrics Brussels 17

SIOP 2

• 1984-1989 • 446 patients registered, 364 randomised • Randomised study of pre-RT chemotherapy: ➢ Procarbazine, VCR, MTX • High-risk cases based on SIOP 1 parameters routinely given post-RT VCR/CCNU chemo • No benefit for pre-RT chemotherapy • Radiotherapy dose randomisation (35 Gy vs 25 Gy) for low-risk cases ➢ Bailey CC et al, Med Pediatr Oncol 1995; 25: 166-178