paediatrics Brussels 17

Reduced Health Status Following Pre-RT Chemotherapy and Craniospinal Irradiation • PNET-3 Study (1992-2000) – Randomised Study of Pre-RT chemotherapy vs RT alone • 73% of 147 eligible patients aged 6.6 to 24.3 years were assessed at a mean of 7.2 years after diagnosis • Health status was significantly poorer in the group treated in the CSI plus CT arm of the trial • Also trends to poorer outcomes for behaviour and quality of life scores • The CSI plus CT group were also significantly more restricted physically and needed more therapeutic and educational support

➢ Bull KS, Spoudeas HA, Yadegarfar G, Kennedy CR ➢ J Clin Oncol 2007; 25: 4239-4245