paediatrics Brussels 17

HIT 91, Patients aged 6-18 Kortmann et al, 2000, IJROBP 46, 269-279

• 1991 - 1997 • 158 patients enrolled, 137 randomised • Sandwich chemotherapy (ifosfamide, etoposide, MTX, cisplatin, cytarabine) vs post- RT CVP • Overall 3 year RFS 70% • M0: 72%, M1: 65%, M2/3: 30%

• M0-1 – Pre-RT chemotherapy: 65% • Immediate RT: 78% (p = <0.03)