paediatrics Brussels 17

WNT Medulloblastoma

• Very good prognosis • Long-term survival > 90% • Majority have classical histology • Beta-catenin nucleo-positivity, CTNNB1 gene mutations, and monosomy 6 • Rarely the WNT subgroup may include large cell/anaplastic cases. Can occur at all ages, but is infrequent in infants • M:F ratio approximately 1:1