paediatrics Brussels 17

SHH Medulloblastoma

• Include TP53 -mutant and TP53 -wildtype subgroups • Named after the sonic hedgehog signalling pathway, considered to drive tumour initiation in the majority of cases • Frequency bimodal, and is frequent in both infants aged less than 3 years and adults • M:F ratio approximately 1:1. • Prognosis similar to Group 4 and intermediate between WNT and Group 3