paediatrics Brussels 17

SHH Medulloblastoma

• Majority of nodular/desmoplastic MBs are included within the SHH subgroup. However around 50% of SHH subgroup MB have other histological subtypes, including classical, large cell/anaplastic, and MBEN varieties.

• Individuals with germline mutations of the SHH receptor PTCH have Gorlin’s syndrome