paediatrics Brussels 17

Group 3 Medulloblastoma • Subgroup of MB with the worst prognosis • Majority classical histology and include the majority of large-cell/anaplastic tumours • M > F, and arise in infants and older children, but only rarely in adults • Frequently present with metastases. • Characterized by high-level amplification of the MYC proto-oncogene, and almost all cases exhibit aberrant MYC expression • Group 3 MB genome exhibits high levels of genomic instability and often harbours gains of chromosomes 1q, 7, and 17q, and deletions of 10q, 11, 16q, and 17p.