paediatrics Brussels 17

PNET5 – SHH-TP53

Nr. 11

“SKK-like” chemotherapy (with i.ventr. MTX): w1: Doxorubicin (or Carbopla$n)/VCR w3, w5: HD-MTX/VCR w7: Carbopla$n/VCR Radiotherapy (with weekly VCR 1,5mg/m 2 ) : Germline TP53mut M0: Focal RT Safety margin 23.4 Gy, tumor 54.0 Gy, Germline TP53mut M+:CSI 23.4 Gy , tumor 54.0 Gy Soma$c TP53mut : CSI 36.0 Gy, tumor 54.0 Gy

Key inclusion criteria: - SHH MB with TP53 muta$on - TP53 germline evalua$on mandatory - All histology subtypes - M0 and M+ - >3-5 years with no upper age limit

MRI

MRI

MRI

MRI

MRI

MRI

LP

SKK like SKK like

+VCR

OP Chemotherapy Radiotherapy

Vinblas$n

≤4w 16w ≤4w 6w * In pa$ents with local radiotherapy only

4*- 6w

24w