paediatrics Brussels 17

PNET5 – WNT-HR

Nr. 12

Key inclusion criteria: - WNT posi$ve with HR-features: - age ≥ 16 years and /or - M+ and/or - R+ - CMB, DMB or LCAMB - MYC/MYCN nega$ve or posi$ve - WNT without CTNNB1 muta$on (if not germline APC-muta$on, rare)

Radiotherapy: <16 years and ≥ 16 years without metastasis: CSI 23.4 Gy, primary tumor 54.0 Gy

≥ 16 years and metastasis: CSI 36.0 Gy , primary tumor 54.0 Gy

MRI

MRI

MRI

MRI

MRI

LP

6w 3w

A B A B A B

( A B)

OP Radiotherapy

Chemotherapy

≤4 w 6w 6w

27 -36w (≥ 16 years)