paediatrics Brussels 17

Medulloblastoma Differences between adults and children • Location: in children tends to arise in the vermis, whereas in adults the cerebellar hemisperes are primarily involved • Histopathological subtype: in children the majority of histological subtypes consist of the classical variant. In adults, the desmoplastic variant is frequently found • Lesser frequency of metastatic disease: in children generally 30%. In adult series the incidence is 8-13%