paediatrics Brussels 17

Clinical studies in localized Ewing’s sarcoma

Tumor size as prognostic factor (< or > 8 cm) (ES- 79), with less prognostic relevance when more intensive treatment is used (EW-92)

St. Jude studies

Tumor site as the most important prognostic factor (extremity vs axial vs pelvis) (ET-1)

UKCCSG/MRC studies

Importance of high dose alkylating agents (ET-2)

CESS studies

Tumor volume (< or > 100 ml) and histological response (CESS-81) as prognostic factors Tumor volume (< or > 200 ml) and histologic response as prognostic factors (CESS-86); intensive treatment with Ifo for high risk pts

EICESS studies

Type of local therapy, stage, histologic response