paediatrics Brussels 17

Timeline of major changes in CT

1970

Dactinomycin, cyclophosphamide, vincristine

Doxorubicin + VAC (IESS-I Study)

High-dose doxorubicin and high-dose cyclophosphamide (IESS-II Study)

Ifosfamide and etoposide + VACA (vincristine, doxorubicin , cyclophosphomide, and dactinomycin (IESS-III Study)

Today

The standard of care today is a 5-6 drugs regimen of vincristine, doxorubicin, cyclophosphamide, actinomycin- D, ifosfamide, and etoposide