BCRB 2018

19/09/2018

Cancer Stem Cells (CSCs)

• Self-renewal • Capability to develop into multiple lineages • Chemo- and radiation resistant • Formation of spheres in suspension culture • Generation of tumors when transplanted in immunodeficient mice with limited number of cells

Jordan et. al. NEJM 2006

Measuring CSC content

Stem Cells

CD44

CD24

Clonogenics

Smit et. al. Radiother Oncol 2013