BCRB 2018

19/09/2018

Cancer stem cells

Red is CD44 Green is pimonidazole

Hypoxia?

Smit et. al. Radiother Oncol 2013

CSC derived organoids?

Organoid surviving fraction

1

0,9

0,8

Chemo

0,7

0,6

0,5

0,4 Survivalfraction

Chemo + Rad 2 Gy

0,3

0,2

0,1

0

0

1

2

3

4

Chemo dose

Boj et al Cell 2015