ESTRO 2025 - Abstract Book

S2372

Interdisciplinary – Other

ESTRO 2025

Data collection and service review is ongoing, and Patient Reported Outcome Measures (PROMs) are being evaluated.

Keywords: MULTIDISCIPLINARY, INTEGRATED PATHWAY

References ¹Verdonck-de Leeuw, I; Dawson, C; Licitra, Jesper Grau Eriksen, l; Hosal, S; Singer, S; Laverty, D.P; Golusinski, W; Machczynski, P; Varges Gomes, A; Girvalaki, C; Simon, C; Leemans, R. European Head and Neck Society recommendations for head and neck cancer survivorship care. Oral Oncology, 2022; Volume 133 https://doi.org/10.1016/j.oraloncology.2022.106047 2 Beeram, M; Kennedy, A; Hales, N. Barriers to comprehensive multidisciplinary head and neck care in a community oncology practice. American Society of Clinical Oncology Educational Book 2021; 41 https://doi.org/10.1200/EDBK_320967

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Digital Poster Tumour blood flow response to exercise in patients with localised and locally advanced prostate cancer: a proof-of-concept study Oliver Schumacher 1,2 , Robert U Newton 1,2 , Raphael Chee 1,3 , Ronny Low 4 , Dennis R Taaffe 1,2 , Nigel Spry 1 , David Joseph 1,5 , Colin Tang 1,6 , Daniel A Galvão 1,2 1 Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Australia. 2 School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia. 3 Radiation Oncology, GenesisCare, Joondalup, Australia. 4 Radiology, Envision Medical Imaging, Wembley, Australia. 5 Radiation Oncology, 5D Clinics, Claremont, Australia. 6 Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, Australia Purpose/Objective Tumour hypoxia resulting from inadequate tumour blood perfusion is a major limiting factor in radiotherapy that contributes to treatment resistance [1]. Exercise has been proposed as a potential strategy to improve the efficacy of cancer treatments by modulating tumour blood flow and reducing hypoxia [2]. However, current evidence is largely based on preclinical research. The purpose of this study was to investigate how a short bout of moderate-to vigorous intensity aerobic exercise affects tumour perfusion in prostate cancer patients scheduled for external beam radiotherapy. Material/Methods Patients with newly diagnosed localised or locally advanced prostate cancer who were to commence external beam radiotherapy were recruited for this proof-of-concept study. Tumour blood flow was assessed using dynamic contrast-enhanced magnetic resonance imaging. Semi-quantitative tumour perfusion parameters (wash-in, wash out, and initial area under the signal intensity curve [iAUC]) were calculated and assessed at rest (baseline) and immediately after an exercise bout (48h after baseline scan). Aerobic exercise consisted of performing step-ups at moderate-to-vigorous intensity for 10-15 minutes. Data were analysed using paired-samples t-test or Wilcoxon signed-rank test, as appropriate. Sensitivity analysis was conducted where outliers were removed from the data. Results In total, 11 participants were included in the analysis. Participants were a mean (SD) age of 75.7 (3.1) years and body mass index of 27.5 (2.7) kg/m 2 . Median (IQR) Gleason score was 7 (7-8) and tumour stage ranged from T2aN0 to T3aN0. Mean (SD) lesion size was 13.3 (5.2) mm and 94% of tumours were in the peripheral zone. Four participants were on androgen deprivation therapy. In the main analysis, there was no significant difference in tumour blood flow after exercise (Table 1). However, when outliers were removed, wash-in significantly increased by 0.066 (95% CI, 0.024 to 0.109; p=.008; n=8), reflecting a 96% change in blood flow compared to baseline (range, 2% to 350%).