ESTRO 2025 - Abstract Book

S2373

Interdisciplinary – Other

ESTRO 2025

Wash-out remained unchanged in the sensitivity analysis (mean difference, -0.002; 95% CI, -0.007 to 0.003; p=.317; n=9).

Conclusion Findings of this proof-of-concept study are that exercise can increase blood flow in the tumour microenvironment of patients with localised and locally advanced prostate cancer, potentially sensitising the tumour to radiotherapy when performed before treatment fractions. However, larger trials are needed to confirm these results and determine the impact of exercise on tumour hypoxia as well as treatment efficacy.

Keywords: exercise, tumour blood flow, prostate cancer

References 1. Barker HE, Paget JT, Khan AA, Harrington KJ. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer . 2015;15(7):409-425. doi:10.1038/nrc3958 2. Schumacher O, Galvão DA, Taaffe DR, Chee R, Spry N, Newton RU. Exercise modulation of tumour perfusion and hypoxia to improve radiotherapy response in prostate cancer. Prostate Cancer Prostatic Dis . 2021;24(1):1-14. doi:10.1038/s41391-020-0245-z

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Digital Poster Impact of radical radiotherapy in elderly patients Jorge G Güemes, Claudia C Pantoja, Javier R de la Peña, Noelia M Cerrato, Eva C López, María Dolores P Cabrera, Jose Z Ortuño, Celia G Torres, Alfonso V Díaz, Olga Engel, Pilar S Ots Radiation Oncology, Rey Juan Carlos Hospital, Madrid, Spain Purpose/Objective Elderly cancer patients are more vulnerable to cancer treatment. This study wants to assess whether radical radiotherapy (RT) with or without chemotherapy (CTX), has an impact on the physical, functional and nutritional status of the elderly patients. Material/Methods In this prospective unicentric observational study, patients ≥ 70 years old receiving 15 or more radical RT fractions and ECOG 0-1 were included. Before starting treatment demographic, anthropometric, bioimpedanciometry, dynamometry data, risk of frailty with the G8 test, assessment of functional capacity (SPPB), risk of falls, risk of sarcopenia with the SARC_F test, risk ok malnutrition with de Nutriscore test and patient-related quality of life with