ESTRO PT 2018

Prospective Comparison of Outcomes in Prostate Cancer Patients Treated with Photons or Protons-a proposal to PCORI • To answer the question of whether observed improved outcome rates with protons are real and reproducible, a prospective clinical trial is needed. • A large patient population is required to prove small differences. • It would not be feasible to accrue such a population with a randomized study design because of patient preference. • Therefore we are proposing a prospective comparison of outcomes in non-randomized cohorts of prostate cancer patients treated with proton therapy or photon based therapy