ESTRO37_ProgrammeBook

INTERDISCIPLINARY RADIOBIOLOGY CLINICAL BRACHYTHERAPY PHYSICS RTT YOUNG

SUNDAY 22 APRIL 2018

hypoxia will be discussed. Examples will be given from recent research on ULK1, the antimalarial drug atovaquoone and inhibitors of ATR- and Chk1-signaling. Chair: H. Lyng (Norway) Co-Chair: F. Hunter (New Zealand) 14:30 > Understanding and targeting the underlying drivers of tumor hypoxia Speaker: B. Wouters (Canada), D. Cojocari, J. Zhang, T. McKee, M. Zaidi, M. Koritzinksy

SP-0337

14:55 > Targeting oxygen consumption

Speaker: G. Higgins (United Kingdom)

SP-0338

15:20 > Targeting hypoxia with DNA repair inhibitors Speaker: R. Syljuasen (Norway)

SP-0339

SYMPOSIUM Proton therapy in head and neck cancer: patient selection, validation and future directions 14:30 - 15:45  | ROOM AUDITORIUM A. Lin will discuss the rationale and need for comparative evidence in support of proton therapy for H&N cancer; the current methods for prospective comparisons; challenges and pitfalls with current approaches as well as alternatives for consideration: model based-approaches. D. Scandurra will provide a description of the patient selection procedure and plan comparison workflow; a practical overview of the proton planning process, including robust optimisation, evaluation of target coverage under uncertainties, and calculation of NTCP; and planning comparison results since clinical operation of the first proton facility as well as in-silico, retrospective planning studies for a range of H&N indications A. Jensen will discuss the incidence, characteristics, standard treatment of ACC; the rationale for dose escalation, neutron experience; particle therapy and rationale; carbon ion experience; prospective data: outcomes and toxicities; cost-effectiveness; C12 for re-irradiation. Chair: H. Langendijk (The Netherlands) Co-Chair: E. Troost (Germany) 14:30 > Model-based clinical validation of proton therapy in head and neck cancer Speaker: A. Lin (USA), J.C. Rwigema, J. Langendijk, J. Lukens, S. Swisher-McClure, J. Langendijk 14:55 > Advanced selection procedures for proton therapy in head and neck cancer patients Speaker: D. Scandurra (The Netherlands)

SP-0340

SP-0341

Programme and Exhibition Guide | SCIENTIFIC PROGRAMME

123